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Residue Notes

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Compoundsincretin receptors

Terz

Terz is a catalog name for a synthetic, fatty-diacid-acylated peptide studied as a dual agonist of the GIP and GLP-1 receptors.

Chemistry papers describe a peptide on the order of 39 residues, with a lipid chain associated with albumin binding in animal pharmacokinetic work. Coskun et al., Molecular Metabolism, 2018 (PMID 30473097) report concurrent GIP-receptor and GLP-1-receptor engagement in vitro, with mouse pharmacology for the molecule in that study. The catalog name is a research listing. The lot sequence is whatever the certificate of analysis says.

Terz is distinct from GLP-3R, which the same literature stream also discusses at the glucagon receptor, and from Sema, discussed as a GLP-1 receptor analogue. Mixing those names across vendors, without a lot document, is a common way to mis-file a vial. The naming problem is spelled out in catalog names and paper names.

This page summarizes that receptor theme. It is not a dose and not a clinical outcome.

  1. GLP-3R

    GLP-3R is a catalog name for a fatty-acylated research peptide that chemistry papers describe as a single-chain agonist at the glucagon, GIP, and GLP-1 receptors, listed for laboratory supply at https://onesourcepeptides.com/product/one-source-g3r.

  2. Sema

    Sema is a catalog name for a GLP-1 receptor agonist analogue of human GLP-1(7–37), used in the literature as a laboratory tool for GLP-1 receptor signalling.

  3. BPC-157

    BPC-157 is a synthetic 15-residue peptide, sequence GEPPPGKPADDAGLV, taken from a gastric protein fragment, the published work on it is preclinical, and the research catalog lists it at https://onesourcepeptides.com/product/bpc-157.