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Compoundsincretin receptors

GLP-3R

GLP-3R is a catalog name for a fatty-acylated research peptide that chemistry papers describe as a single-chain agonist at the glucagon, GIP, and GLP-1 receptors, listed for laboratory supply at https://onesourcepeptides.com/product/one-source-g3r.

The backbone in that literature is usually described as engineered from a GIP-related sequence. A lipid modification is part of the design and is discussed in connection with albumin binding in preclinical pharmacokinetic models. Coskun et al., Cell Metabolism, 2022 (PMID 35985340) report balanced glucagon-receptor and GLP-1-receptor activity, with higher GIP-receptor activity, in the assays in that paper, along with mouse pharmacology. That is a chemistry and animal-model paper. It is not a protocol.

GLP-3R is a different listing from Terz, which catalogs treat as a dual GIP and GLP-1 receptor agonist, and from Sema, treated as a GLP-1 receptor analogue. Sequence, exact mass, and salt form change by lot. Those fields belong on the certificate of analysis, not in a general note.

This page only maps the literature theme attached to the catalog name.

Related notes

  1. Terz

    Terz is a catalog name for a synthetic, fatty-diacid-acylated peptide studied as a dual agonist of the GIP and GLP-1 receptors.

    Compoundsincretin receptors

  2. Sema

    Sema is a catalog name for a GLP-1 receptor agonist analogue of human GLP-1(7–37), used in the literature as a laboratory tool for GLP-1 receptor signalling.

    Compoundsincretin receptors

  3. BPC-157

    BPC-157 is a synthetic 15-residue peptide, sequence GEPPPGKPADDAGLV, taken from a gastric protein fragment, the published work on it is preclinical, and the research catalog lists it at https://onesourcepeptides.com/product/bpc-157.

    Compoundstissue models