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Residue Notes

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Compoundsamylin

Cagrilintide

Cagrilintide is a lipidated amylin analogue studied as an amylin-receptor ligand, and it is not a GLP-1 peptide.

Catalogs sometimes place it near incretin listings because both turn up in metabolic-signalling papers. The receptors are different. Amylin is a pancreatic peptide hormone with its own receptor complexes. GLP-1, GIP, and glucagon are a separate set, which is why this note does not file the compound under Sema, Terz, or GLP-3R.

A lipid chain on the analogue is discussed in the chemistry literature in connection with albumin binding in animal pharmacokinetic models. Kruse et al., Journal of Medicinal Chemistry (PMID 34288673) report structure–activity work on that class of lipidated analogue. That is chemistry context. It is not a protocol, and it is not a statement about human use.

Confirm the lot on the certificate of analysis before treating any vial as the sequence a paper studied.

Related notes

  1. GLP-3R

    GLP-3R is a catalog name for a fatty-acylated research peptide that chemistry papers describe as a single-chain agonist at the glucagon, GIP, and GLP-1 receptors, listed for laboratory supply at https://onesourcepeptides.com/product/one-source-g3r.

    Compoundsincretin receptors

  2. Terz

    Terz is a catalog name for a synthetic, fatty-diacid-acylated peptide studied as a dual agonist of the GIP and GLP-1 receptors.

    Compoundsincretin receptors

  3. Sema

    Sema is a catalog name for a GLP-1 receptor agonist analogue of human GLP-1(7–37), used in the literature as a laboratory tool for GLP-1 receptor signalling.

    Compoundsincretin receptors